ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2019, Vol. 50 ›› Issue (8): 1536-1544.doi: 10.11843/j.issn.0366-6964.2019.08.002
• REVIEW • Previous Articles Next Articles
ZHOU Di1,2, WANG Yinchen3, TIAN Xingzhou1*, CHEN Jiaqi1, XIN Hailiang4, NI Mengmeng1, BAN Chao5, PAENGKOUM Pramote5, WU Wenxuan1, CHEN Shengchang1, XIA Xianlin1
Received:2019-02-11
Online:2019-08-23
Published:2019-08-23
CLC Number:
ZHOU Di, WANG Yinchen, TIAN Xingzhou, CHEN Jiaqi, XIN Hailiang, NI Mengmeng, BAN Chao, PAENGKOUM Pramote, WU Wenxuan, CHEN Shengchang, XIA Xianlin. Study of the Mechanism of Anthocyanins Enhancing Antioxidant Capacity in Ruminants[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(8): 1536-1544.
| [1] RAKESH S U,PATIL P R,MANE S R.Use of natural antioxidants to scavenge free radicals:a major cause of diseases[J].Int J PharmTech Res,2010,2(2):1074-1081. [2] TIAN X Z,PAENGKOUM P,PAENGKOUM S,et al.Comparison of forage yield,silage fermentative quality,anthocyanin stability,antioxidant activity,and in vitro rumen fermentation of anthocyanin-rich purple corn (Zea mays L.) stover and sticky corn stover[J].J Integr Agric,2018,17(9):2082-2095. [3] CHAUDHARI B K,SINGH M,MAURYA P K,et al.Stress markers in the plasma and milk of Murrah buffaloes during summer[J].Agri Rev,2013,34(1):21-35. [4] SHARMA N,SINGH N K,SINGH O P,et al.Oxidative stress and antioxidant status during transition period in dairy cows[J].Asian-Austral J Anim Sci,2011,24(4):479-484. [5] CRTES C,PALIN M F,GAGNON N,et al.Mammary gene expression and activity of antioxidant enzymes and concentration of the mammalian lignan enterolactone in milk and plasma of dairy cows fed flax lignans and infused with flax oil in the abomasum[J].Br J Nutr,2012,108(8):1390-1398. [6] GUO H H,LI D,LING W H,et al.Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ[J].J Lipid Res,2011,52(5):908-922. [7] LIN L Z,SUN J,CHEN P,et al.UHPLC-PDA-ESI/HRMS/MS(n) analysis of anthocyanins,flavonol glycosides,and hydroxycinnamic acid derivatives in red mustard greens (Brassica juncea Coss variety)[J].J Agric Food Chem,2011,59(22):12059-12072. [8] HAN K H,SEKIKAWA M,SHIMADA K I,et al.Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats[J].Br J Nutr,2006,96(6):1125-1134. [9] WU X L,PITTMAN H E,PRIOR R L.Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption[J].J Agric Food Chem,2006,54(2):583-589. [10] YOU J Y,KIM J,LIM J,et al.Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species[J].Theriogenology,2010,74(5):777-785. [11] 汪水平,彭希豪,牛有军,等.葡萄籽提取物原花青素对肉兔屠宰性能与肉质的影响[J].畜牧兽医学报,2014,45(7):1135-1141. WANG S P,PENG X H,NIU Y J,et al.Effects of grape seed proanthocyanidin extracts on slaughter performance and meat quality of meat rabbit[J].Acta Veterinaria et Zootechnica Sinica,2014,45(7):1135-1141.(in Chinese) [12] FELGINES C,TALAVÉRA S,TEXIER O,et al.Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans[J].J Agric Food Chem,2005,53(20):7721-7727. [13] CHANG H,YU B,YU X P,et al.Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo[J].Nutr Cancer,2010,62(8):1128-1136. [14] FORMICA J V,REGELSON W.Review of the biology of quercetin and related bioflavonoids[J].Food Chem Toxicol,1995,33(12):1061-1080. [15] BLOOR S J,ABRAHAMS S.The structure of the major anthocyanin in Arabidopsis thaliana[J].Phytochemistry,2002,59(3):343-346. [16] KONCZAK I,ZHANG W.Anthocyanins-more than nature's colours[J].J Biomed Biotechnol,2004,2004(5):239-240. [17] CASTAÑEDA-OVANDO A,DE LOURDES PACHECO-HERNÁNDEZ M,PÁEZ-HERNÁNDEZ M E,et al.Chemical studies of anthocyanins:a review[J].Food Chem,2009,113(4):859-871. [18] ADEDOKUN O,TITILOPE K,AWODUGBA A O.Review on natural dye-sensitized solar cells (DSSCs)[J].Int J Eng Technol,2016,2(2):34-41. [19] REIN M J.Copigmentation reactions and color stability of berry anthocyanins[D].Finland,Helsinki:University of Helsinki,2005. [20] CLIFFORD M N.Anthocyanins-nature,occurrence and dietary burden[J].J Sci Food Agric,2000,80(7):1063-1072. [21] AOKI H,KUZE N,KATO Y.Anthocyanins isolated from purple corn (Zea mays L.)[J].Foods Food Ingredients J Jpn,2002,199:41-45. [22] HOU Z H,QIN P Y,ZHANG Y,et al.Identification of anthocyanins isolated from black rice (Oryza sativa L.) and their degradation kinetics[J].Food Res Int,2013,50(2):691-697. [23] MOJICA L,BERHOW M,DE MEJIA E G.Black bean anthocyanin-rich extracts as food colorants:physicochemical stability and antidiabetes potential[J].Food Chem,2017,229:628-639. [24] WHO.Toxicological evaluation of certain food additives and contaminants[R].Geneva:WHO Food Additives Series,1996. [25] HOSODA K,MIYAJI M,MATSUYAMA H,et al.Effect of supplementation of purple pigment from anthocyanin-rich corn (Zea mays L.) on blood antioxidant activity and oxidation resistance in sheep[J].Livest Sci,2012,145(1-3):266-270. [26] HOSODA K,ERUDEN B,MATSUYAMA H,et al.Effect of anthocyanin-rich corn silage on digestibility,milk production and plasma enzyme activities in lactating dairy cows[J].Anim Sci J,2012,83(6):453-459. [27] SONG T H,HAN O K,PARK T I,et al.Anthocyanin stability and silage fermentation quality of colored barley[J].J Korean Soc Grassland Forage Sci,2012,32(4):335-342. [28] LEATHERWOOD W L.The effect of anthocyanins from purple-fleshed sweetpotato on in vitro fermentation by rumen microbial cultures[D].Raleigh:North Carolina State University,2013. [29] 伍树松,贺喜,伍小松,等.花青素作为饲料添加剂的应用前景[J].动物营养学报,2011,23(12):2097-2104. WU S S,HE X,WU X S,et al.The use of anthocyanins as a feed additive[J].Chinese Journal of Animal Nutrition,2011,23(12):2097-2104.(in Chinese) [30] GONTHIER M P,DONOVAN J L,TEXIER O,et al.Metabolism of dietary procyanidins in rats[J].Free Radical Bio Med,2003,35(8):837-844. [31] ISHIDA K,KISHI Y,OISHI K,et al.Effects of feeding polyphenol-rich winery wastes on digestibility,nitrogen utilization,ruminal fermentation,antioxidant status and oxidative stress in wethers[J].Anim Sci J,2015,86(3):260-269. [32] CORREDDUF,NUDDA A,BATTACONE G,et al.Effects of grape seed supplementation,alone or associated with linseed,on ruminal metabolism in Sarda dairy sheep[J].Anim Feed Sci Technol,2015,199:61-72. [33] 童津津,张华,孙铭维,等.采用Illumina MiSeq测序技术分析葡萄籽原花青素对奶牛体外瘤胃发酵产甲烷菌区系的影响[J].动物营养学报,2019,31(1):314-323. TONG J J,ZHANG H,SUN M W,et al.Effects of grape seed procyanidine on Methanogens flora of in vitro rumen fermentation of dairy cows using Illumina MiSeq sequencing technology[J].Chinese Journal of Animal Nutrition,2019,31(1):314-323.(in Chinese) [34] 杨德莲,童津津,张婕,等.葡萄籽原花青素对奶牛瘤胃体外发酵参数及微生物区系的影响[J].动物营养学报,2018,30(2):717-725. YANG D L,TONG J J,ZHANG J,et al.Effects of grape seed procyanidine on rumen fermentation parameters and microflora of dairy cows in vitro[J].Chinese Journal of Animal Nutrition,2018,30(2):717-725.(in Chinese) [35] CEVALLOS-CASALS B A,CISNEROS-ZEVALLOS L.Stability of anthocyanin-based aqueous extracts of Andean purple corn and red-fleshed sweet potato compared to synthetic and natural colorants[J].Food Chem,2004,86(1):69-77. [36] KHOO H E,AZLAN A,TANG S T,et al.Anthocyanidins and anthocyanins:colored pigments as food,pharmaceutical ingredients,and the potential health benefits[J].Food Nutr Res,2017,61(1):1361779. [37] CAVALCANTI R N,SANTOS D T,MEIRELES M A A.Non-thermal stabilization mechanisms of anthocyanins in model and food systems - An overview[J].Food Res Int,2011,44(2):499-509. [38] MARTÍNEZ C,JORDÁN M J,MOÑINO M I,et al.Identification of polyphenolic components in Murciano-Granadina goat milk and suckling goat kid plasma[J].Planta Med,2007,73(9):923. [39] HE J,MAGNUSON B A,LALA G,et al.Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation[J].Nutr Cancer,2006,54(1):3-12. [40] NETZEL M,NETZEL G,KAMMERER D R,et al.Cancer cell antiproliferation activity and metabolism of black carrot anthocyanins[J].Innov Food Sci Emerg Technol,2007,8(3):365-372. [41] MANGAN J L.Nutritional effects of tannins in animal feeds[J].Nutr Res Rev,1988,1(1):209-231. [42] JORDÁN M J,MOÑINO M I,MARTÍNEZ C,et al.Introduction of distillate rosemary leaves into the diet of the Murciano-granadina goat:transfer of polyphenolic compounds to goats' milk and the plasma of suckling goat kids[J].J Agric Food Chem,2010,58(14):8265-8270. [43] TIAN X Z,PAENGKOUM P,PAENGKOUM S,et al.Short communication:purple corn (Zea mays L.) stover silage with abundant anthocyanins transferring anthocyanin composition to the milk and increasing antioxidant status of lactating dairy goats[J].J Dairy Sci,2019,102(1):413-418. [44] 胡俊菁.葡萄籽原花青素对奶牛抗氧化状况和酮病等指标的影响[D].南宁:广西大学,2017. HU J J.Effects of feeding grape seed procyanidins on antioxidant status and ketosis-related indicators in dairy cows[D].Nanning:Guangxi University,2017.(in Chinese) [45] NARAYAN M S,NAIDU K A,RAVISHANKAR G A,et al.Antioxidant effect of anthocyanin on enzymatic and non-enzymatic lipid peroxidation[J].Prostag Leukotr ESS,1999,60(1):1-4. [46] PROVENZA F D,VILLALBA J J.The role of natural plant products in modulating the immune system:an adaptable approach for combating disease in grazing animals[J].Small Ruminant Res,2010,89(2-3):131-139. [47] NIEZEN J H,CHARLESTON W A G,ROBERTSON HA,et al.The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes[J].Vet Parasitol,2002,105(3):229-245. [48] HOUDIJK J G M,JACKSON F,COOP R L,et al.Rapid improvement of immunity to Teladorsagia circumcincta is achieved through a reduction in the demand for protein in lactating ewes[J].Int J Parasitol,2006,36(2):219-227. [49] MORAIS C A,DE ROSSO V V,ESTADELLA D,et al.Anthocyanins as inflammatory modulators and the role of the gut microbiota[J].J Nutr Biochem,2016,33:1-7. [50] CORREDDU F,GASPA G,PULINA G,et al.Grape seed and linseed,alone and in combination,enhance unsaturated fatty acids in the milk of Sarda dairy sheep[J].J Dairy Sci,2016,99(3):1725-1735. [51] JORDāO A M,CORREIA A C.Relationship between antioxidant capacity,proanthocyanidin and anthocyanin content during grape maturation of Touriga Nacional and Tinta Roriz grape varieties[J].S Afr J Enol Vitic,2012,33(2):214-224. [52] NGO THI M S.Utilization of anthocyanin-rich Napier grass silage in growing goat diets[D].Thailand:Suranaree University of Technology,2018. [53] 姜良,黄秀芬,刘杉杉,等.紫玉米花色苷抑制牛传染性鼻气管炎病毒在牛肾细胞中增殖的研究[J].中国畜牧兽医,2014,41(8):127-130. JIANG L,HUANG X F,LIU S S,et al.Study on purple corn anthocyanin inhibits replication of infectious bovine Rhinotracheitis virus on bovine kidney cells[J].China Animal Husbandry & Veterinary Medicine,2014,41(8):127-130.(in Chinese) [54] 涂军,黄云飞,胡俊菁,等.葡萄籽原花青素对产后奶牛血浆中H2O2和酮体含量的影响[J].广西畜牧兽医,2018,34(2):100-102. TU J,HUANG Y F,HU J J,et al.Effects of grape seed proanthocyanidins on the plasma hydrogen peroxide and ketone bodies of postpartum dairy cows[J].Guangxi Journal of Animal Husbandry & Veterinary Medicine,2018,34(2):100-102.(in Chinese) [55] MITTLER R.Oxidative stress,antioxidants and stress tolerance[J].Trends Plant Sci,2002,7(9):405-410. [56] SCHOGOR A L B,PALIN M F,SANTOS G T,et al.Mammary gene expression and activity of antioxidant enzymes and oxidative indicators in the blood,milk,mammary tissue and ruminal fluid of dairy cows fed flax meal[J].Br J Nutr,2013,110(10):1743-1750. [57] 宿孝奇.酮病奶牛氧化应激特征及原花青素对奶牛氧化应激的影响[D].南宁:广西大学,2015. SU X Q.Characetristics of oxidative stress in cows with ketosis and the effect of adding procyanidins on oxidative stress in cows[D].Nanning:Guangxi University,2015.(in Chinese) [58] 邹须永,胡俊菁,冯馨莹,等.喂食原花青素对产后奶牛血浆抗氧化指标的影响[J].广西畜牧兽医,2017,33(2):83-85. ZOU X Y,HU J J,FENG X Y,et al.Effects of procyanidins on plasma antioxidant parameters in postpartum dairy cows[J].Guangxi Journal of Animal Husbandry & Veterinary Medicine,2017,33(2):83-85.(in Chinese) [59] PARK S Y,LEE J H,KIM Y K,et al.Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation[J].J Pharmacol Exp Ther,2005,312(3):1241-1248. [60] SURH Y J,NA H K.NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals[J].Genes Nutr,2008,2(4):313-317. [61] HEISS E,HERHAUS C,KLIMO K,et al.Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms[J].J Biol Chem,2001,276(34):32008-32015. [62] HOLLANDS W,BRETT G M,RADREAU P,et al.Processing blackcurrants dramatically reduces the content and does not enhance the urinary yield of anthocyanins in human subjects[J].Food Chem,2008,108(3):869-878. [63] JEONG J W,LEE W S,SHIN S C,et al.Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-κB and Akt/MAPKs signaling pathways[J].Int J Mol Sci,2013,14(1):1502-1515. [64] ELGENDY R,CASTELLANI F,PALAZZO F,et al.RNA sequencing-based transcriptome profiling of dairy cows fed with a polyphenol-rich grape pomace-supplemented diet[J].Ital J Anim Sci,2017,16(S1):137-138. [65] DE MARCHI F E,PALIN M F,SANTOS G T D,et al.Flax meal supplementation on the activity of antioxidant enzymes and the expression of oxidative stress- and lipogenic-related genes in dairy cows infused with sunflower oil in the abomasum[J].Anim Feed Sci Tech,2015,199:41-50. [66] TIAN X Z,XIN H L,PAENGKOUM P,et al.Effects of anthocyanin-rich purple corn (Zea mays L.) stover silage on nutrient utilization,rumen fermentation,plasma antioxidant capacity,and mammary gland gene expression in dairy goats[J].J Anim Sci,2019,97(3):1384-1397. [67] CHEN C Y,YI L,JIN X,et al.Inhibitory effect of delphinidin on monocyte-endothelial cell adhesion induced by oxidized low-density lipoprotein via ROS/p38MAPK/NF-κB pathway[J].Cell Biochem Biophys,2011,61(2):337-348. [68] NIOI P,NGUYEN T,SHERRATT P J,et al.The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation[J].Mol Cell Biol,2005,25(24):10895-10906. [69] ZHANG X,YANG Y,WU Z F,et al.The modulatory effect of anthocyanins from purple sweet potato on human intestinal microbiota in vitro[J].J Agric Food Chem,2016,64(12):2582-2590. [70] HE J L,ZHOU Z W,YIN J J,et al.Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway[J].Drug Des Dev Ther,2014,9:127-146. [71] HUANG W,SHANG Y F,CHEN P L,et al.Basic leucine zipper (bZIP) domain transcription factor MBZ1 regulates cell wall integrity,spore adherence,and virulence in Metarhizium robertsii[J].J Biol Chem,2015,290(13):8218-8231. [72] DOMITROVIC R.The molecular basis for the pharmacological activity of anthocyans[J].Curr Med Chem,2011,18(29):4454-4469. [73] YE J,YAO J P,WANG X,et al.Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury[J].Mol Med Rep,2016,13(4):3083-3091. [74] KRUGER M J,DAVIES N,MYBURGH K H,et al.Proanthocyanidins,anthocyanins and cardiovascular diseases[J].Food Res Int,2014,59:41-52. [75] TIAN X Z.Effects of anthocyanin-rich purple corn (Zea mays L.) stover silage on antioxidant activities in dairy goats[D].Thailand:Suranaree University of Technology,2017. [76] SAKATANI M,SUDA I,OKI T,et al.Effects of purple sweet potato anthocyanins on development and intracellular redox status of bovine preimplantation embryos exposed to heat shock[J].J Reprod Dev,2007,53(3):605-614. [77] SPECIALE A,CIMINO F,SAIJA A,et al.Bioavailability and molecular activities of anthocyanins as modulators of endothelial function[J].Genes Nutr,2014,9(4):404. [78] LIMA L S,PALIN M F,SANTOS G T,et al.Effects of supplementation of flax meal and flax oil on mammary gene expression and activity of antioxidant enzymes in mammary tissue,plasma and erythrocytes of dairy cows[J].Livest Sci,2015,176:196-204. |
| [1] | XIA Chunqiu, WAN Fachun, LIU Lei, SHEN Weijun, XIAO Dingfu. Valine: Biological Function and Application in Livestock and Poultry Diets [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4502-4513. |
| [2] | REN Hongyang, ZHENG Linfeng, WANG Zili, WANG Hongliang. Effects of Mixing Materials on Crude Protein Content and Fermentation Quality of Whole Corn Silage [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4526-4536. |
| [3] | WU Zhili, YAO Junhu, LEI Xinjian. Research Progress of Rumen-protected Glucose on Nutritional Regulation in Perinatal Dairy Animals [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3173-3182. |
| [4] | LIU Jinmei, CHANG Wenhuan, CHEN Zhimin, ZHENG Aijuan, QIU Kai, WANG Zedong, LIU Guohua, CAI Huiyi. Research Progress of Pectin and Its Microbial Degradation [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2723-2731. |
| [5] | ZHAO Wei, Mahmoud M. Abdelsattar, CHAI Jianmin, WANG Xin, DIAO Qiyu, ZHANG Naifeng. Research Progress of Rumen Microbiota Transplantation and Its Application [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1792-1803. |
| [6] | SUN Yufan, YU Panyuan, CHEN Hongyu, TAN Yiqing, CHEN Xiabing, ZHANG Tengfei, GAO Ting, ZHOU Rui, LI Lu. Evaluation of the Efficacy of Potassium Diformate in the Prevention of Salmonella Infection and the Effect on Intestinal Flora [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2101-2113. |
| [7] | YANG Zihui, DONG Zhen, WU Huilan, TAN Bin, ZENG Jianguo. Analysis of the Material Basis and Mechanism of Action of Antioxidant Function of Taraxacum mongolicum based on Network Pharmacology [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2170-2185. |
| [8] | ZHUO Ruhao, LIU Qingyang, ZHONG Xiang. Advances in the Roles of Curcumin on Regulating Gut Microbiota and Antiviral Effects [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 473-483. |
| [9] | ZHAO Yaya, CHANG Jiang, JU Ning, LUO Yulong. Mechanism of Plant Polyphenols Addition in Diet Regulating Meat Color Stability [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 36-47. |
| [10] | LI Kai, ZHAO Yuqing, ZHONG Ruqing, LIU Lei, YAN Honglin, ZHOU Jianchuan, CHEN Liang, ZHANG Hongfu. Comparative Study on Evaluation of the Available Energy of Corn and Sorghum of Chicken by Free Feeding Method and Tube Feeding Method [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3907-3916. |
| [11] | SUN Dong, CAI Yinchuan, JIANG Siyu, LI Xuan, HAO Gang. Molecular Design, Structure and Activity Analysis of Antimicrobial Peptide Tachyplesin I [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1905-1913. |
| [12] | WANG Meng, LI Shangmin, SHEN Dan, HAN Guofeng, LI Yansen, DOU Xinhong, LI Chunmei. Effects of Dietary Different Whole-Plant Corn Silage Levels on Growth Performance, Slaughter Performance, Meat Quality and Serum Biochemical Parameters of Geese [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3501-3511. |
| [13] | WANG Ruixiu, CHEN Zhongwei, LIU Qiang, ZHUANG Su. Effects of Synbiotics on Meat Quality, Antioxidant Capacity and Immune Function of Cherry Valley Ducks [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(9): 2522-2533. |
| [14] | ZHANG Xiaojing, ZHANG Yangyang, ZHANG Xiaofeng, QIAO Hongxing, BIAN Chuanzhou. Isolation and Identification of Aflatoxin B1 Degrading Bacillus amyloliquefaciens and Its in vitro Detoxification Effect [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2291-2301. |
| [15] | JIA Hongmin, MA Yonghang, HE Pingli, QIAO Shiyan. Effects of Excessive Lysine on Weaned Piglets and Their Intestinal Epithelial Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1912-1926. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
